In this review, we discuss how two evolutionarily conserved pathways at the interface of DNA replication and repair, template switching and break-induced replication, lead to the deleterious large-scale expansion of trinucleotide DNA repeats that cause numerous hereditary diseases. We highlight that these pathways, which originated in prokaryotes, may be subsequently hijacked to maintain long DNA microsatellites in eukaryotes. We suggest that the negative mutagenic outcomes of these pathways, exemplified by repeat expansion diseases, are likely outweighed by their positive role in (...) maintaining functional repetitive regions of the genome such as telomeres and centromeres. Break-induced replication and template switching are conserved mechanisms of replication fork restart. They do not cause microsatellite instability in prokaryotes, but promote repeat expansion in eukaryotes. We suggest that TS and BIR persisted in eukaryotes despite their mutagenic potential because they help maintain long repetitive telomeres and centromeres. (shrink)

This paper examines two questions about scientists’ search for knowledge. First, which search strategies generate discoveries effectively? Second, is it advantageous to diversify search strategies? We argue pace Weisberg and Muldoon (2009) that, on the first question, a search strategy that deliberately seeks novel research approaches need not be optimal. On the second question, we argue they have not shown epistemic reasons exist for the division of cognitive labor, identifying the errors that led to their conclusions. Furthermore, we generalize the (...) epistemic landscape model, showing that one should be skeptical about the benefits of social learning in epistemically complex environments. (shrink)

It is certainly the case that morality governs the interactions that take place between individuals. But what if morality exists because of these interactions? This book, first published in 2007, argues for the claim that much of the behaviour we view as 'moral' exists because acting in that way benefits each of us to the greatest extent possible, given the socially structured nature of society. Drawing upon aspects of evolutionary game theory, the theory of bounded rationality, and computational models of (...) social networks, it shows both how moral behaviour can emerge in socially structured environments, and how it can persist even when it is not typically viewed as 'rational' from a traditional economic perspective. This book also provides a theory of how moral principles and the moral sentiments play an indispensable role in effective choice, acting as 'fast and frugal heuristics' in social decision contexts. (shrink)

The God of Jesus -- The nature of God: an unanswerable question? -- The nature of God in Christian tradition -- And our God?

Multiarm bandit problems have been used to model the selection of competing scientific theories by boundedly rational agents. In this paper, I define a variable-arm bandit problem, which allows the set of scientific theories to vary over time. I show that Roth-Erev reinforcement learning, which solves multiarm bandit problems in the limit, cannot solve this problem in a reasonable time. However, social learning via preferential attachment combined with individual reinforcement learning which discounts the past, does.

The General Data Protection Regulation (GDPR) of the EU confirms the protection of personal data as a fundamental human right and affords data subjects more control over the way their personal information is processed, shared, and analyzed. However, where data are processed by artificial intelligence (AI) algorithms, asserting control and providing adequate explanations is a challenge. Due to massive increases in computing power and big data processing, modern AI algorithms are too complex and opaque to be understood by most data (...) subjects. Articles 15 and 22 of the GDPR provide a modest regulatory framework for automated data processing by, among other things, mandating that data controllers inform data subjects about when it is being used, and its logic and ramifications. Nevertheless, due to the phrasing of the articles and the numerous exceptions they allow, doubts have arisen about their effectiveness. In this paper, we empirically evaluate the quality and effectiveness of AI disclosures as mandated by the GDPR. By means of an online survey (N = 835), we investigated how data subjects expect to be informed about the automated processing of their data. We then conducted a content analysis of the AI disclosures of N = 100 companies and organizations. The combined findings reveal that current GDPR-mandated disclosures do not meet the expectations and needs of data subjects. Explanations drawn up following the guidelines of the generic formulations of the GDPR differ widely and are often vague, incomplete and lack transparency. In our conclusions we identify a path towards standardizing and optimizing AI information notices. (shrink)

Strong reciprocators possess two behavioural dispositions: they are willing to bestow bene ts on those who have bestowed bene ts, and they are willing to punish those who fail to bestow bene ts according to some social norm. There is no doubt that peoples' behaviour, in many cases, agrees with what we would expect if people are strong reciprocators, and Fehr and Henrich argue that many people are, in fact, strong reciprocators. They also suggest that strongly reciprocal behaviour may be (...) brought about by specialised cognitive architecture produced by evolution. I argue that specialised cognitive architecture can play a role in the production of strongly reciprocal behaviour only in a very attenuated sense, and that the evolutionary foundations of strong reciprocity are more likely cultural than biological. (shrink)

Jacobi held a position of unparalleled importance in late eighteenth and early nineteenth century intellectual history. This includes his role in bringing about the close of the Enlightenment, his central part in shaping the reception of Kant's philosophy and German idealism, and his influence on the development of Romanticism and existentialism.

Early German Romanticism sought to respond to a comprehensive sense of spiritual crisis that characterised the late eighteenth century. The study demonstrates how the Romantics sought to bring together the new post-Kantian idealist philosophy with the inheritance of the realist Platonic-Christian tradition. With idealism they continued to champion the individual, while from Platonism they took the notion that all reality, including the self, participated in absolute being. This insight was expressed, not in the language of theology or philosophy, but through (...) aesthetics, which recognised the potentiality of all creation, including artistic creation, to disclose the divine. In explicating the religious vision of Romanticism, this study offers a new historical appreciation of the movement, and furthermore demonstrates its importance for our understanding of religion today. (shrink)

Platonism has played a central role in Christianity and is essential to a deep understanding of the Christian theological tradition. At times, Platonism has constituted an essential philosophical and theological resource, furnishing Christianity with an intellectual framework that has played a key role in its early development, and in subsequent periods of renewal. Alternatively, it has been considered a compromising influence, conflicting with the faith's revelatory foundations and distorting its inherent message. In both cases the fundamental importance of Platonism, as (...) a force which Christianity defined itself by and against, is clear. Written by an international team of scholars, this landmark volume examines the history of Christian Platonism from antiquity to the present day, covers key concepts, and engages issues such as the environment, natural science and materialism. (shrink)

Evolutionary game theoretic accounts of justice attempt to explain our willingness to follow certain principles of justice by appealing to robustness properties possessed by those principles. Skyrms (1996) offers one sketch of how such an account might go for divide-the-dollar, the simplest version of the Nash bargaining game, using the replicator dynamics of Taylor and Jonker (1978). In a recent article, D'Arms et al. (1998) criticize his account and describe a model which, they allege, undermines his theory. I sketch a (...) theory of evolutionary explanations of justice which avoids their methodological criticisms, and develop a spatial model of divide-the-dollar with more robust convergence properties than the models of Skyrms (1996) and D'Arms et al. (1998). (shrink)

Decision theory faces a number of problematic gambles which challenge it to say what value an ideal rational agent should assign to the gamble, and why. Yet little attention has been devoted to the question of what an ideal rational agent is, and in what sense decision theory may be said to apply to one. I show that, given one arguably natural set of constraints on the preferences of an idealized rational agent, such an agent is forced to be indifferent (...) among entire families of goods, and hence cannot choose among them. This result illustrates the dangers of speaking of the choices of an ?ideal rational agent? when one does not make precise the exact nature of the idealizing assumptions. The result may also be viewed as providing an upper bound on the kinds of idealizing assumptions which can be made for rational agents, beyond which the very concept of choice becomes attenuated. (shrink)

The Pasadena game is an example of a decision problem which lacks an expected value, as traditionally conceived. Easwaran (2008) has shown that, if we distinguish between two different kinds of expectations, which he calls ‘strong’ and ‘weak’, the Pasadena game lacks a strong expectation but has a weak expectation. Furthermore, he argues that we should use the weak expectation as providing a measure of the value of an individual play of the Pasadena game. By considering a modified version of (...) the Pasadena game, I argue that weak expectations may provide a very poor measure of the value of an individual play of the game, and hence should not be used to value individual plays unless further information is taken into consideration. (shrink)

In this wide-ranging conversation, Michael Hardt reflects on recent transformations within Empire. Several unique themes emerge concerning power and pedagogy as they intersect with subjectivity and global crisis. Drawing on the common in conjunction with the tradition of love in education uncovers a different path that attends to today’s real political, ecological, and social needs. Finally, a focus on collectivity points to a possible strategy—collective intellectuality—for educators to revise traditional notions of leadership to encourage more ethical, democratic, and sustainable futures. (...) Yet, what this looks like in practice remains for us to imagine. (shrink)

Appeals to human nature are ubiquitous, yet historically many have proven ill-founded. Why? How might frequent errors be remedied towards building a more robust and reliable scientific study of human nature? Our aim is neither to advance specific scientific or philosophical claims about human nature, nor to proscribe or eliminate such claims. Rather, we articulate through examples the types of errors that frequently arise in this field, towards improving the rigor of the scientific and social studies. We seek to analyze (...) such claims rhetorically, cognitively, and epistemically. Namely, how do we think about human nature? Claims about human nature, we show, are susceptible to widely exhibited deficits in cognitive tendencies such as framing, confirmation bias, satisficing, and teleological perspectives, as well as motivated reasoning. Such missteps foster methodological, empirical, and psychological mistakes and biases. Specifically, they promote the naturalizing error, whereby cultural ideology and values are projected onto an apparently objective description of nature. Concrete remedies are offered to aid scientists in conducting and reporting their research goals and findings more responsibly and effectively (relevant also to educators and other communicators who convey these findings publicly). Recommendations include acknowledging that human nature claims are often context-dependent, seeking multiple critical perspectives, and explicitly labeling uncertainties. (shrink)

Recent years have seen increased interest in the question of whether it is possible to provide an evolutionary game-theoretic explanation for certain kinds of social norms. I sketch a proof of a general representation theorem for a large class of evolutionary game-theoretic models played on a social network, in hope that this will contribute to a greater understanding of the long-term evolutionary dynamics of such models, and hence the evolution of social norms.

With the earliest known reference to angling with a fly dating from the Chou Dynasty, more than 2,300 years ago, it should come as no surprise that when asked to justify their passionate devotion to fly fishing, many anglers will refer to the rich and venerable literature the sport has generated. Ranging from Plutarch's references to Nile fishing in the Life of Antonius, to Pliny the Elder's Historia Naturalis, to the fifteenth century classic, Dame Julian Berner's The Treatyse of Fysshynge (...) wyth an Angle, to the sport's bible, the 17th century The Compleat Angler by Izaak Walton, to literary treatments in the work of authors such as John Donne, Gerard Manley Hopkins, William Butler Yeats, Ezra Pound and Ernest Hemingway, the wealth of literature devoted to fly fishing appears to be out of proportion to what is, ultimately, just a way of seducing an animal with a brain the size of a pea into inhaling a hook upon which some feathers, furs and tinsels have been lashed. What then, one may legitimately ask, is it about this sport that creates fanatical devotion on the part of its practitioners, who tend to regard it with such zeal and passion as is commonly reserved for art and religion? (shrink)

This chapter contains section titled: Kin Selection Reciprocity Group Selection Coercion Mutualism Byproduct Mutualism Local Interactions References.

Largely neglected today, the work of Karl Philipp Moritz was a highly influential source for Early German Romanticism. Moritz considered the form of myth as essential to the absolute nature of the divine subject. This defence was based upon his aesthetic theory, which held that beautiful art was “disinterested”, or complete in itself. For Moritz, Myth, like art, constitutes a totality providing an idiom free from restriction in the imitation of the divine. This examination offers a consideration of Moritz’s aesthetics (...) and mythography, before turning briefly to consider his influence on the authors of Early German Romanticism. An understanding of the role of Moritz’s thought supports a number of recent claims that challenge the conventional reading of Romanticism. At the same time it allows us to see Romanticism’s unconventional realist theological programme, permitting us to overcome the problematic secularising readings of the movement. I would like to thank Kurt Mueller-Vollmer, as well as Fredrick Beiser and Lars Fischer for their help with this project. (shrink)

Rachlin's idea that altruism, like self-control, is a valuable, temporally extended pattern of behavior, suggests one way of addressing common problems in developing a rational choice explanation of individual altruistic behavior. However, the form of Rachlin's explicitly behaviorist account of altruistic acts suffers from two faults, one of which questions the feasibility of his particular behaviorist analysis.

This thesis concerns the relation between the fundamental properties and the powers they confer. The views considered are introduced in terms of their acceptance or rejection of the quiddistic thesis. Essentially the quiddistic thesis claims that properties confer the powers they do neither necessarily nor sufficiently. Quidditism is the view that accepts the quiddistic thesis. The other two views to be considered, the pure powers view and the grounded view reject the quiddistic thesis. The pure powers view supports its denial (...) of the quiddistic thesis with the claim that properties consist in conferring the powers they do; the possession of a property just is the possession of a power. The grounded view, the positive view of this thesis, rejects the idea that properties are constituted by conferring the causal powers they do. Rather on the grounded view, it is the natures of the fundamental properties that metaphysically explain why they confer the powers they do. (shrink)

Novalis was a central figure in early German Romantic philosophy. Whilst the importance of both Fichte and Spinoza for the development of Romanticism is well established, the vital influence of the Platonic tradition in allowing the Romantics to synthesise these divergent philosophies merits closer attention. Essential to the development of Novalis’ thought was his exposure to Plotinus. This examination first sets out the religious and philosophical problems in Germany at the close of the eighteenth century and situates Novalis in relation (...) to this intellectual environment. Following this, a brief survey of Plotinus-scholarship at the close of the eighteenth century in Germany frames how Novalis came into contact with Plotinus through Dieterich Tiedemann. The examination proceeds to consider how Tiedemann shaped Novalis reception of Plotinus and allowed him to develop a synthesis of Spinoza and Fichte. Finally, it briefly examines the poetic realisation of this synthesis through Novalis’ late poetic work. (shrink)

In this volume, critical scholars and educational activists explore the intricate dynamics between the enclosure of global commons and radical visions of a common social future that breaks through the logics of privatization, ecological degradation, and dehumanizing social hierarchies in education. In its institutional and informal configurations alike, education has been identified as perhaps the key stake in this struggle. Insisting on the urgency of an education that breaks free of the bonds of enclosure, the essays included in this volume (...) weave together bright threads of radical thought into a vivid tapestry illustrating a critical framework for enacting a global educational commons. (shrink)

This is the first volume to offer a systematic consideration and comprehensive overview of Christianity’s long engagement with the Platonic philosophical tradition. The book offers a detailed consideration of the most fertile sources and concepts in Christian Platonism, a historical contextualization of its development, and a series of constructive engagements with central questions. Bringing together a range of leading scholars, the volume guides readers through each of these dimensions, uniquely investigating and explicating one of the most important, controversial, and often (...) misunderstood elements of Christian intellectual history. (shrink)

Irenaeus, Coleridge and Gadamer all wrote about religion in distinct historical periods, however the work that each produced reflects the anthropological condition of the middle position. Furthermore, each thinker provides an opportunity for self-reflection about the motivations of faith without requiring the individual to abandon their religious belief in order to do so. In this manner they present a productive alternative to the required external views of the social sciences. The individual's position in mid-creation, his moral freedom and his historical (...) contingence all require the acceptance, commitment and trust of faith. Gnosticism, Empiricist thought and the desire to overcome historical contingency all reveal intellectual impatience in riposte to this condition. This intellectual impatience seeks the absolute without the need for faith. For Irenaeus, Coleridge and Gadamer such absolute, logocentric, complete systems end up alienating man from the reality of the incomplete condition that permeates his existence and the faith-requiring mythos that ultimate realities necessitate in order to be communicated. (shrink)

With a sound mixture of common sense and clear-sighted temperance, 'Political Justice' reconstructs classical philosophy through direct dialogue with modern liberalism, dismantling the fallacies and follies of the latter brick by brick, even while rediscovering the principles of a just political order.

After over 300 years of scrutiny, the subject of Galileo continues to be pursued with unabating intensity. Dava Sobel's Galileo's Daughter points to the popular interest in the man and his legacy. The Catholic Church, understandably interested in dispelling the notion that its censure of Galileo centuries ago is proof positive that religious faith and science as well as ecclesiastical authority and free pursuit of scholarship are irreconcilable, continues to offer explanations. New books, articles and conferences probe both in breadth (...) and in depth the magnetic field charged by Galileo, science, and the Church. Galileo's analysis of the physics of motion has also received considerable attention. In particular, a great deal has been written during the past thirty years about the structure and objectives of three experiments with inclined planes. Galileo had carried them out in Padua and recorded them in his working papers. The assessments of the three experiments differ widely in points of detail, but all regard them as sophisticated, ingenious, and remarkable. This article presents a new critical study of these experiments. Its conclusion is that one of the experiments is indeed a success, but that the other two fail and are abandoned because Galileo did not have a firm enough grip on the underlying physical principles and mathematical relationships. (shrink)

Consider the problem of allocating a scarce resource to people. A fair decision procedure is one where each person has an equal chance of receiving the resource. An unfair decision procedure is one where the chances are not equal. Normally we think that, in an unfair decision procedure, that the correct way to redress the injustice is by rerunning the allocation using a fair decision procedure. In this paper, I show that this actually creates an overall bias favouring one person, (...) and solutions to this problem are counterintuitive, in that they typically involve introducing additional unfair elements into the situation. (shrink)

Whereas The Stag Hunt and the Evolution of Social Structure supplements Evolution of the Social Contract by examining some of the earlier work’s strategic problems in a local interaction setting, no equivalent supplement exists for The Dynamics of Rational Deliberation . In this article, I develop a general framework for modeling the dynamics of rational deliberation in a local interaction setting. In doing so, I show that when local interactions are permitted, three interesting phenomena occur: (a) the attracting deliberative equilibria (...) may fail to agree with any of the Nash equilibria of the underlying game, (b) deliberative dynamics which converged to the same deliberative outcome in The Dynamics of Rational Deliberation may lead to different deliberative outcomes here, and (c) Bayesian deliberation seems to be more likely to avoid nonstandard deliberative outcomes, contrary to the result reported in The Dynamics of Rational Deliberation , which argued in favour of the Brown–von Neumann–Nash dynamics. (shrink)

This symposium discusses J.-L. Dessalles's account of the evolution of language, which was presented in Why we Talk (OUP 2007).

This examination considers the influence of the seventeenth century Cambridge Platonist Cudworth upon the thought of the late eighteenth century German thinker Herder. It focuses upon Herder's use of Cudworth's philosophy to create a revised version of Spinoza's metaphysics. Both Cudworth and Herder were concerned with the problem of determinism. Cudworth outlined a number of difficulties relating to this problem in the thought of Spinoza and proposed amendments, particularly the introduction of the middle principle of plastik, which would mediate between (...) the Ideas of transcendent reason and mechanical materialism. We find these amendments to Spinoza's philosophy also employed in Herder's contribution to the Pantheism Controversy, in which he too offers a revised Spinozism and introduces his own middle principle of Kraft. This demonstrates an important but under-explored English contribution to a key development in German intellectual history. The Pantheism Controversy was an epoch-making event, helping to bring an end to the German Enlightenment and to inaugurate the Romantic movement. Herder's version of Spinoza's thought revived the philosopher's fortunes, and Herder's notion of Kraft became central to Romantic aesthetics. Finally, Herder's use of Cudworth demonstrates the important but overlooked source of Platonic realism in German Romantic thought. (shrink)